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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cb85eee4d21e1c07a57466342e220c2999b030de4e59b6ededd922f9e4f4de53' 
  AND token = 'by2SNk4UTWrCkLf1hjSvz0UjFgBE+/7qAcPTFZ3594I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00010

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}