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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8a33b60bb73b1f4a1d4486948899fdcdf60187289a833d33e34170e2361083b0' 
  AND token = 'A6z5Be2X65VnHafCiyd9IGtWFSyoBbLgCAmmoMR9FbU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}