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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ed41a7cff8ea059bd5c0ff82a089339e92f39c1c43ebfba121dfe9a90f86226' 
  AND token = 'pGUH6eyCSlO6Q+00XFqlqWyQYhqd9ajLNRyQgmx+/Jw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00013

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}