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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '728a86b207f5861a6974df472f88769b931d263629a500a3756486788e3f98a8' 
  AND token = '2EL0rEdE6SJG5cAD7AQ/diAXv0Q3TrBzQTe1hTfwHmk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00013

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}