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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '281c7b1bf34270bceee5977d01b89632584e5d19bf57c40e3530c994249615e8' 
  AND token = 'K2UD8NpMqSU+xbaXTH0hl+xVpq/ri4xaZMjFPRRudqA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00010

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}