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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c08f5baacbfd0ad10d2e2a181accfcf741a1849159a12159d7d9d1c9e59cca0' 
  AND token = 'KV9smfvGc5j9ZsdlIrg2aBKlZXRJekEiLzHVP4nHV+A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00007

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}