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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '285d0edd4b6fa46e56d4c89ae8e665111503a5d9d19f3f1138f774a910490dd2' 
  AND token = 'oO6zdDp2OV/zMSTkN0yMxKtlkgfuAS+ZCO+C3lOanxk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}