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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01bf79cd83c51c386cf0419f4523044aa6d9b6e098ea94922cacfc24e27fe4e4' 
  AND token = 'w/YnDcCVNvlvz/dXy8EvW4rfbB1GtWDjHjM6XWwt0Mc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}