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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5278da4c6288b4bcb12e57c2681de68b4c40a0b4fff2ef30e2654d8027c73576' 
  AND token = 'T9yUuSffIrXTX0wcp8K7eSm8p/0N1eFMtXy0+Jmuz/k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00010

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}