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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22bc08063b20cef9b5e3e5ee42ff0a91f49d8a4aab22eaa1cec098bb44350840' 
  AND token = 'R07YbDLoEGQL85By3589ro0SXbfRr9almzzA538WkDs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00009

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}