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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8dedf4f1b27904d29acf7f5db65266626f46e65563e4e7d902babc53f1c13c20' 
  AND token = 'ajPGgwHGo0+5dMb92MYcw2OC45kMXTVgPbQXMH5hxBw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}