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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46ea2f74672eb0b17c3e2db929aa500b0f4f5e41c3534cb063473eebcd3c8f21' 
  AND token = 'KKM+mTKqVq+iZ4rVnQxnIOrv8fyGjubSK0uGbkxUdF4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}