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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43e200d064a8313f45f047e441bb363a58ae0032390dd3b0430d0a7fc73d1bdc' 
  AND token = 'OEYTNyb+W8kz/U/fwAMFa0V3c3gMedLdvvJ6ZmJM2LI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}