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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ae2542ff9f3a6249c87fc80cd97b84c37b0b4f2ddb69c52c78c1604a43b17454' 
  AND token = 'o3qLX2kDmlnmv1N+8XuqY9FYbl8zcPGsWYUPNLl1XBU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00011

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}