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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '294c01a105a1086b4afe212b2ad53837c21765284e7abf108bdf7c8f0c955e4e' 
  AND token = 'EMyq9N4bbiyV+kklMc7wxW6MoL4rVJTDsVN9Hg42RD4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00010

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}