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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a2f5783791119f2a99d2fd2102dfdf0d5cc610e65a5d7f7e1020fe27176bbd9f' 
  AND token = 'pnUnAbLIsoSetg/5KRpmkQTRqcEnaD2CxmZNPQNcpRI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}