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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd4c220fc43dce3dc2bc85b91f592cac5a2c33b37472d5199ee5d9be483e9d918' 
  AND token = 'nnn0dp5aPGnjHTH/hQfpxBC/Dd+qmcSrP3Pit82zpj8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00009

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}