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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a22198a3c0504362f97a775de9dfb4a12f93447438b3fc971ebdec2326710f00' 
  AND token = '3e49n4T66cfK8zgL/TpcF1bsVxWGCnooSmzDYnfWxxY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00011

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}