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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f6281ede7a25818f595cebf54b4c521a7a81871e690aec54c8b2536f8157eed' 
  AND token = 'x2Dow2kO+dAdLi2p0+6AWkVfQcBqmH0wddcRizgRn5s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00010

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}