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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e97e398bc4bad7dd017b84d0103199a18bf1ed4b71f020376f4c059309e9ccc' 
  AND token = '++99csfz7gfAu//VM2EDaoettb/6ISSWSCpLwRVbrO8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}