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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'dc65f812aaec515ae3887561fd4cc1def490465db0c2da0a2135a7c4a086bf8f' 
  AND token = 'ane0M6ckhprZzuZNYGIXwCVBu9bZGlXkKJEF0EIF8hw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}