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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c66398c2d1f30716ee746c3c5a395038577881108c13b08271cff09d636e2030' 
  AND token = 'RjIAQTS42zsdWEEwhHZaH5vvpHVVwDY6UbmzVxsLh1U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}