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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '454f6a679e614cd0123c8e67b20b3b15cea0aa8b58b82b433c9af49986b43392' 
  AND token = 'fraRp0Cl94lE0OUwxuEA2G7B+JqTAvbHH/SVAaasNKQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}