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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c3a04272e8c25f53cbfdc21caec63837d1ca88a0aa98502fb255a75170fa2e7' 
  AND token = 'HHLoEZOUB1dqw3U6kxtbnTA6oYGWJ1QYUe1xnuLIwZs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00013

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}