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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a1e680f305ecabda9a91fbb34bf7efdf0205b4d936ba5c0facd1f183d0100e1f' 
  AND token = '+TEfXqmj8vTj41BWYcjMJPWD3iyKt/7wREZ+mhTs0E8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00011

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}