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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '235f7fcfbcf2ccabb3c1810d432a37f6302ec57d0b49affbbd023c9885c34901' 
  AND token = '6kDNf7q1HVRVUf0G98Z1UAuUTJ9K4NtpB0eZHaAwAfk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00011

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}