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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '720e7845df4a2fccfd44d5eaf0f81be82c3bf9d4bddedda46aabc012dc01f06b' 
  AND token = 'GZ1xz1++CcYk/tnNELT6AsqzZPvjlhDco1TQ9epUC3A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}