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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65ff7954fe110d7fe5a27d40af2fc6682ec66c6a9861443848d010c898128de8' 
  AND token = 'AECLmJOK4MZZs+RWT3hvTM6zUHcVWCrZ2I3A0ulXJYc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00010

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}