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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd5289e09a5f3c9e7dfc0a2295f4d4139351a046fe869e59ffb99c31ebcb90f0c' 
  AND token = 'QcoxVD1OENspr2W9wtCBvvqFVZdG+cxoA9BRSEc4uQQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00009

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}