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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b7d750fd001f0ee68f649b7cd51e434d4e919b1300cab47fd3e5e91e02718a1' 
  AND token = 'DU7Z2X7qOxWHwy5WwFIE7ZpzIFTe2iZ0OKUbMidxdq4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00011

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}