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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78b8d3eabcc4c77c89909b798b3111e433905c6770c6c2958b8111384920d389' 
  AND token = '9s8a/xPh4EZFf7htNWh64KFjFkfCkBvrOcZltx0uqbg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00009

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}