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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d187ebffb7e5f22e171a12f748a9679291bed42c8cb4060477e9590390f06fc' 
  AND token = 's33x++T6XXTbeSg4X7ZhyNxIPlTLnppHegfVrEfm1d4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}