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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75a80e963f93587a0757cbdb58407628bf94f9b7196381750354c4200fc5f9e5' 
  AND token = 'D0hXKuI1Y7vJNACPVkmzMtIOxaZkEEuhb7wz+GybkbM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00009

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}