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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49b971a9e3564686a1e30c56489eba04221dc3820bc46faafc2b35365f024044' 
  AND token = '9jUQWApnbLG/qrbxk3klRSoxF1vc9hV9ZYW2WG1/2EQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00010

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}