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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '19045095a0a331ab2182e423c6e04e57df8dceda319f2ace36775bf30305add4' 
  AND token = 'fSo0oxiQvDU+FRA74g67s/Ee/8XdPSSrB/q4xM9BT0o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}