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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1180d8f28b951ba1ba731bebd025dcd6574837c2a8c55255fb63c529122f1bb1' 
  AND token = 'WZ5YDdadRIbat6zpBfXKaO0rIuRhoLM5jc25IM+BTRs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00009

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}