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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e1e0bf0c21398af92df65882a031f32a734e64871fae9ab5404c7b99e5aedc0' 
  AND token = '+tzYzXHXfVjRIPeCPxggUuXiM6706esGInWcNtykuo0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}