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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8435f180a75fb67c94ece0d7861520b3596a5560e8524435cbcd123e14d4e8a' 
  AND token = 'RdOKW4q1XWS85+wRWBr5Q9Fue+BJI8GZCEfR8PTTAlo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}