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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd546d1072c07784d243ced17c3f11a033326df80d725350f6c82f267f3d33dd8' 
  AND token = 'tH5E0mVYE4rhWYnSFhVc8Z0tZmR3mB5ElvdtGvcXBEw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00011

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}