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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12d680d49ed785ad016a1d74e6b6aeb4832c967d9b6ffc6ff4d6d53c3e42deec' 
  AND token = 'UqEvB1JUNQSow3RPwaIaeSeXC/cK/qOA504IY39OhIc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}