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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2258f873337705dbb97f2303899f1cb7c1d7f9b8551d44e091fcb6dcf34c46e8' 
  AND token = 'hNY1Iz2gOeV8PdNkTtgUeDxSnSd4qrdyYMLpYwRuqwk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}