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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ebeb648506c80f36663695b57b7b5de54868dd7db0aee10a60bed63af65c21a' 
  AND token = '49PzbiOFssysvRoOmD+HErKqkTH6FC1kbPTjAADix4g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00010

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}