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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49bd981a4a5dd67780c280a56fbe2e1df1f066a52c2c1dd04a650b7b537d2aaf' 
  AND token = 'M/Cci7Qj7h7sQZBXiATgqZUH7V3u9z5T1UMRVLVnd9A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}