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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1074cdbea0b9f7a416129aa052a8c0c150c63b8cd9d65746faa424bb493ac344' 
  AND token = 'CzUdkrPC3+MDuOMHZJchYtRmeRxcvIcPS1+4v/pOZRQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}